-The International Organization for Standardization (ISO) has defined nanomaterial as a material with any external dimension on the nanoscale (\u2018nano-object\u2019) or having an internal or surface structure in the nanoscale (\u2018nanostructured material\u2019)
\n\uff08\u8a33\uff1aISO\u306b\u304a\u3044\u3066\u3001nanomaterial\uff08\u30ca\u30ce\u6750\u6599\uff09\u3092\u3001\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u306e\u5916\u5f62\u5bf8\u6cd5\u3092\u6301\u3064\u6750\u6599\uff08\u30ca\u30ce\u7269\u4f53\uff09\u82e5\u3057\u304f\u306f\u3001\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u306e\u5185\u90e8\u69cb\u9020\u53c8\u306f\u8868\u9762\u69cb\u9020\u3092\u6301\u3064\u6750\u6599\uff08\u30ca\u30ce\u69cb\u9020\u6750\u6599\uff09\u3068\u5b9a\u7fa9\u4ed8\u3051\u3066\u3044\u308b\u3002\uff09
\n-\u2018Nanoscale\u2019 is defined as ranging from approximately 1 to 100 nm
\n\uff08\u8a33\uff1a\u300c\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb\u300d\u3068\u306f\u3001\u304a\u304a\u3088\u305d1\u304b\u3089100\u30ca\u30ce\u30e1\u30fc\u30bf\u30fc\u306e\u5bf8\u6cd5\u306e\u3053\u3068\u3092\u3044\u3046\u3002\uff09<\/p><\/blockquote>\n
\u3000\u4e0a\u8a18\u306e\u5185\u5bb9\u3088\u308a\u3001EFSA\u3067\u306f\u3001\u5927\u304d\u3055\u304c1\uff5e100\u30ca\u30ce\u30e1\u30fc\u30bf\u30fc\u306e\u7269\u8cea\u3001\u82e5\u3057\u304f\u306f\u305d\u306e\u69d8\u306a\u5927\u304d\u3055\u306e\u5185\u90e8\u69cb\u9020\u3084\u8868\u9762\u69cb\u9020\u306e\u7269\u8cea\u3092\u30ca\u30ce\u6750\u6599\uff08nanomaterial\uff09\u3068\u3057\u3066\u3044\u308b\u69d8\u3067\u3059\u3002
\n\u3000\u53c8\u3001\u3053\u306e\u30ca\u30ce\u6750\u6599\uff08nanomaterial\uff09\u306b\u8a72\u5f53\u3059\u308b\u3082\u306e\u306e\u7c92\u5ea6\u5206\u5e03\u306b\u3064\u3044\u3066\u3001EFSA\u306f\u540c\u30ac\u30a4\u30c0\u30f3\u30b9\u306b\u304a\u3044\u3066\u4ee5\u4e0b\u306e\u901a\u308a\u8a18\u8f09\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n
-The European Commission recommended that a material with 50% or more of the particles in the number size distribution in the nanoscale (1\u2013100 nm) should be regarded a nanomaterial.
\n\uff08\u8a33\uff1aEU\u3067\u306f\u30ca\u30ce\u30b9\u30b1\u30fc\u30eb(1\u304b\u3089100\u30ca\u30ce\u30e1\u30fc\u30bf\u30fc)\u306e\u5927\u304d\u3055\u306e\u7c92\u5b50\u306e\u7c92\u5ea6\u5206\u5e03\u304c50%\u4ee5\u4e0a\u306e\u7d20\u6750\u3092nanomaterial\uff08\u30ca\u30ce\u6750\u6599\uff09\u3068\u307f\u306a\u3059\u3053\u3068\u3092\u63a8\u5968\u3057\u3066\u3044\u308b\u3002\uff09
\n-Although this recommendation is currently under review, and has not yet been adopted under the relevant regulatory frameworks, the Scientific Committee advises to take this and any future reviews into consideration when assessing safety of materials consisting of particles.
\n\uff08\u8a33\uff1a\u3053\u306e\u63a8\u5968\u5185\u5bb9\u306f\u73fe\u5728\u691c\u8a0e\u6bb5\u968e\u3067\u3042\u308a\u3001\u95a2\u9023\u6cd5\u898f\u306e\u67a0\u7d44\u307f\u5185\u3067\u672a\u63a1\u7528\u3067\u306f\u3042\u308b\u304c\u3001Scientific Committee(\u79d1\u5b66\u59d4\u54e1\u4f1a)\u306f\u3001\u7c92\u5b50\u304b\u3089\u6210\u308b\u6750\u6599\u306e\u5b89\u5168\u6027\u3092\u8abf\u67fb\u3059\u308b\u969b\u306b\u306f\u3001\u3053\u306e\u8003\u3048\u65b9\u3068\u3053\u308c\u306b\u57fa\u3065\u304f\u305d\u306e\u5f8c\u306e\u8a55\u4fa1\u3092\u3059\u3079\u3066\u8003\u616e\u306b\u5165\u308c\u308b\u69d8\u52e7\u544a\u3057\u3066\u3044\u308b\u3002\uff09<\/p><\/blockquote>\n
\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306e\u300c\u30ca\u30ce\u6750\u6599\uff08nanomaterial\uff09\u300d\u3068\u3057\u3066\u306e\u4f4d\u7f6e\u4ed8\u3051\u306b\u3064\u3044\u3066<\/h2>\n
\n
\u3000\u3053\u308c\u306b\u5bfe\u3057\u3001EFSA\u306f\u4eca\u56de\u306e\u898b\u89e3\u3067\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\uff08Titanium dioxide: E171\uff09\u306b\u3064\u3044\u3066\u4ee5\u4e0b\u306e\u901a\u308a\u8ff0\u3079\u3066\u3044\u307e\u3059\u3002<\/p>\n
Titanium dioxide E171 contains at most 50% of particles in the nano range (i.e. less than 100 nanometres) to which consumers may be exposed.
\n\uff08\u8a33\uff1a\u4e8c\u9178\u5316\u30c1\u30bf\u30f3E171\u306f\u3001\u6d88\u8cbb\u8005\u304c\u3055\u3089\u3055\u308c\u308b\u53ef\u80fd\u6027\u304c\u3042\u308b\u30ca\u30ce\u30ec\u30d9\u30eb\uff08\u5373\u3061100\u30ca\u30ce\u30e1\u30fc\u30bf\u30fc\u4ee5\u4e0b\uff09\u306e\u7c92\u5b50\u306e\u542b\u6709\u91cf\u306f\u591a\u304f\u306650%\u3067\u3042\u308b\u3002\uff09<\/p><\/blockquote>\n
\u3000\u4e00\u898b\u3001\u30ca\u30ce\u6750\u6599\u306e\u5b9a\u7fa9\u304b\u3089\u5916\u308c\u308b\u69d8\u306a\u66f8\u304d\u65b9\u3092\u3057\u3066\u3044\u307e\u3059\u304c\u3001\u305d\u306e\u4e00\u65b9\u3067\u3001\u524d\u8ff0\u306e\u30ac\u30a4\u30c0\u30f3\u30b9\u306e\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u306b\u95a2\u3059\u308b\u8003\u3048\u65b9\u304c\u6dfb\u52a0\u7269\u306b\u521d\u3081\u3066\u9069\u7528\u3055\u308c\u305f\u3068\u3057\u3066\u304a\u308a\u3001\u66f4\u306b\u4ee5\u4e0b\u306e\u901a\u308a\u7d9a\u3051\u3066\u3044\u307e\u3059\u3002<\/p>\n
Uncertainty around the characterisation of the material used as the food additive (E 171) was also highlighted, in particular with respect to particle size and particle size distribution of titanium dioxide used as E 171.
\n\uff08\u8a33\uff1a\u98df\u54c1\u6dfb\u52a0\u7269E171\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u7d20\u6750\u3001\u3059\u306a\u308f\u3061E171\u3068\u3057\u3066\u4f7f\u7528\u3055\u308c\u3066\u3044\u308b\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306e\u3068\u308a\u308f\u3051\u7c92\u5f84\u4e26\u3073\u306b\u7c92\u5ea6\u5206\u5e03\u3092\u3069\u3046\u7279\u5fb4\u4ed8\u3051\u3059\u308b\u304b\u304c\u78ba\u5b9a\u3057\u3066\u3044\u306a\u3044\u3053\u3068\u304c\u6ce8\u76ee\u3055\u308c\u3066\u3044\u308b\u3002\uff09<\/p><\/blockquote>\n
\u3000\u3053\u306e\u3053\u3068\u304b\u3089\u3001\u4e0a\u8a18\u7c92\u5ea6\u5206\u5e03\u306e\u5b9a\u7fa9\u306b\u3064\u3044\u3066\u306f\u3001\u5fc5\u305a\u3057\u3082\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306b\u5f53\u3066\u306f\u307e\u308b\u304b\u306f\u78ba\u5b9f\u3067\u306f\u306a\u3044\u3068\u306e\u8003\u3048\u65b9\u3092\u793a\u3057\u3066\u3044\u308b\u3082\u306e\u3068\u601d\u308f\u308c\u307e\u3059\u3002
\n\u3000\u305d\u3057\u3066\u305d\u306e\u4e0a\u3067\u3001\u4ee5\u4e0b\u306e\u901a\u308a\u8a18\u8f09\u3057\u3066\u304a\u308a\u3001\u907a\u4f1d\u5b50\u6bd2\u6027\u306b\u3064\u3044\u3066\u6307\u6458\u3057\u3066\u3044\u307e\u3059\u3002<\/p>\n
the Panel\uff08\u6ce8\uff09<\/sup> concluded that titanium dioxide can no longer be considered safe as a food additive. A critical element in reaching this conclusion is that we could not exclude genotoxicity concerns after consumption of titanium dioxide particles. After oral ingestion, the absorption of titanium dioxide particles is low, however they can accumulate in the body
\n\uff08\u6ce8\uff09<\/sup>EFSA\u2019s expert Panel on Food Additives and Flavourings (FAF)
\n\uff08\uff1d\u98df\u54c1\u6dfb\u52a0\u7269\u4e26\u3073\u306b\u9999\u6599\u306b\u95a2\u3059\u308bEFSA\u5c02\u9580\u59d4\u54e1\u4f1a(FAF)\uff09
\n\uff08\u8a33\uff1a\u59d4\u54e1\u4f1a\u3067\u306f\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306f\u5b89\u5168\u3068\u3059\u308b\u3053\u3068\u306f\u51fa\u6765\u306a\u3044\u3068\u7d50\u8ad6\u4ed8\u3051\u305f\u3002\u305d\u306e\u7d50\u8ad6\u306b\u81f3\u308b\u6c7a\u3081\u624b\u3068\u306a\u3063\u305f\u306e\u306f\u3001\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306e\u7c92\u5b50\u3092\u6d88\u8cbb\u3057\u305f\u5f8c\u306e\u907a\u4f1d\u6bd2\u6027\u306e\u61f8\u5ff5\u304c\u62ed\u3044\u304d\u308c\u306a\u3044\u70b9\u3067\u3042\u308b\u3002\u7d4c\u53e3\u6442\u53d6\u5f8c\u3001\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306e\u7c92\u5b50\u306e\u5438\u53ce\u6027\u306f\u4f4e\u3044\u304c\u3001\u4f53\u5185\u306b\u84c4\u7a4d\u3055\u308c\u308b\u3002\uff09<\/p><\/blockquote>\n\u3000\u6700\u5f8c\u306bEFSA\u306f\u898b\u89e3\u3092\u6b21\u306e\u3088\u3046\u306b\u7d50\u3093\u3067\u3044\u307e\u3059\u3002<\/p>\n
\nEFSA concluded that a concern for genotoxicity of TiO2 particles cannot be ruled out. Based on this concern, EFSA\u2019s experts no longer consider titanium dioxide safe when used as a food additive. This means that an Acceptable Daily Intake (ADI) cannot be established for E171.
\n\uff08\u8a33\uff1aEFSA\u306f\u3001\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306e\u7c92\u5b50\u306b\u3064\u3044\u3066\u907a\u4f1d\u5b50\u6bd2\u6027\u306e\u61f8\u5ff5\u304c\u306c\u3050\u3044\u5207\u308c\u306a\u3044\u3068\u7d50\u8ad6\u4ed8\u3051\u3066\u304a\u308a\u3001\u3053\u306e\u61f8\u5ff5\u3092\u57fa\u306b\u3001\u98df\u54c1\u6dfb\u52a0\u7269\u3068\u3057\u3066\u306e\u5b89\u5168\u6027\u306f\u3082\u306f\u3084\u62c5\u4fdd\u51fa\u6765\u306a\u3044\u3068\u3057\u3066\u3044\u308b\u3002\u3053\u306e\u3053\u3068\u306f\u3001E171\u306b\u306f\u4e00\u65e5\u6442\u53d6\u8a31\u5bb9\u91cf\uff08ADI\uff09\u304c\u8a2d\u5b9a\u51fa\u6765\u306a\u3044\u3053\u3068\u3092\u610f\u5473\u3059\u308b\u3002\uff09<\/p><\/blockquote>\n
\u3000\u3053\u308c\u307e\u3067\u8ff0\u3079\u3066\u6765\u305f\u30ca\u30ce\u6750\u6599\uff08nanomaterial\uff09\u306b\u5bfe\u3059\u308b\u5b9a\u7fa9\u4ed8\u3051\u306b\u57fa\u3065\u304f\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306b\u95a2\u3059\u308bEFSA\u306e\u4eca\u56de\u306e\u898b\u89e3\u306b\u3064\u3044\u3066\u3001\u6700\u7d42\u7684\u306b\u5404\u95a2\u9023\u6cd5\u4ee4\u306b\u3069\u3046\u53cd\u6620\u3055\u305b\u308b\u304b\u306e\u5224\u65ad\u306f\u3001EU\u5404\u52a0\u76df\u56fd\u306e\u624b\u306b\u59d4\u306d\u3089\u308c\u308b\u3053\u3068\u306b\u306a\u308a\u307e\u3059\u304c\u3001\u305d\u306e\u5f8c\u6b27\u5dde\u59d4\u54e1\u4f1a\u3067\u306f\u5c02\u9580\u5bb6\u4f1a\u8b70\u304c\u958b\u304b\u308c\u3001EU\u5185\u3067\u306e\u4f7f\u7528\u7981\u6b62\u304c\u63d0\u8a00\u3055\u308c\u305f\u6a21\u69d8\u3067\u3059\u3002\u4eca\u56de\u306e\u4e8b\u4f8b\u3092\u76ae\u5207\u308a\u306b\u3001\u4eca\u5f8c\u3082EU\u3067\u306f\u98df\u54c1\u6dfb\u52a0\u7269\u306b\u3064\u3044\u3066\u3001\u300c\u30ca\u30ce\u6750\u6599\u300d\u3068\u3044\u3046\u5207\u308a\u53e3\u3067\u540c\u69d8\u306e\u5b89\u5168\u6027\u8a55\u4fa1\u304c\u4e0b\u3055\u308c\u308b\u53ef\u80fd\u6027\u3082\u3042\u308b\u3068\u8003\u3048\u3066\u304a\u308a\u3001\u305d\u306e\u52d5\u5411\u304c\u6ce8\u76ee\u3055\u308c\u308b\u3068\u3053\u308d\u3067\u3059\u3002<\/p>\n
\u3000\u30ca\u30ce\u30c6\u30af\u30ce\u30ed\u30b8\u30fc\u3092\u5229\u7528\u3057\u305f\u5546\u54c1\u3092\u53d6\u308a\u6271\u3063\u3066\u304a\u3089\u308c\u308b\u7686\u69d8\u3001\u7279\u306b\u3044\u308f\u3086\u308b\u300c\u30ca\u30ce\u6750\u6599\uff08nanomaterial\uff09\u300d\u306b\u8a72\u5f53\u3059\u308b\u7d20\u6750\u3092\u542b\u3080\u98df\u54c1\u3092EU\u3078\u8f38\u51fa\u3059\u308b\u3053\u3068\u3092\u8003\u3048\u3089\u308c\u3066\u304a\u3089\u308c\u308b\u7686\u69d8\u306b\u304a\u304b\u308c\u307e\u3057\u3066\u3001\u4eca\u56de\u306e\u4e8c\u9178\u5316\u30c1\u30bf\u30f3\u306b\u95a2\u3059\u308bEFSA\u306e\u898b\u89e3\u304c\u5c11\u3057\u3067\u3082\u53c2\u8003\u306b\u306a\u308c\u3070\u5e78\u3044\u3067\u3059\u3002<\/p>\n
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